Some of the compounds presented are investigational or are being investigated for uses that have not been approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), or other health authorities.
Scientific Congress Publications
Supported by Bayer Pharmaceuticals
ESC 2026
Systolic blood pressure variability and effect of finerenone treatment in patients with chronic kidney disease and type 2 diabetes: a FIDELITY analysis
- Higher SBP variability (expressed as SD, CoV, and VIM) was associated with increased risk of CV and kidney outcomes.
- Finerenone lowered the risk of CV and kidney outcomes vs placebo irrespective of SBP variability, and did not increase SBP variability vs placebo.
- Hyperkalaemia and TEAEs were similar across treatment arms and SBP variability quartiles, and increased as SBP variability increased.
- High pre-treatment SBP variability (especially CoV) may be a good predictor of CV outcomes.
- Treatment effect of finerenone was not modified by SBP variability and may confer benefit compared with placebo in those with high SBP variability.
- Finerenone did not increase SBP variability compared with placebo.
CoV, coefficient of variation; CV, cardiovascular; SBP, systolic blood pressure; SD, standard deviation; TEAE, treatment-emergent adverse event; VIM, variation independent of the mean.
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